Abstract
Rats were fed for 8 week with standard laboratory diet (SLD, 27 mg Fe/kg diet) or iron enriched diet (FE, 400 mg Fe/kg diet) and had blood withdrawals (w) 0,5 ml/100g body weight, 8 times. The following items were assessed in blood: haemoglobin concentration and respiratory burst (RB), iron stores in liver tissue.
In serum were evaluated prohepcidin, iron and bone metabolism markers: osteokalcin (OC), N-terminal propeptid of procollagen I (PINP), C-terminal telopeptide of collagen I (CTx) and tartare resistant acid phosphatase (TRACP). Bone mineral density (BMD) was measured.
Repeated blood withdrawals and iron enriched diet conributed to stimulation reactivity of scavenger cells, elevation activity of osteoclast, stimulation of osteoblast with subsequent positive effect on quality of bone tissue