Alendronate lowers cholesterol synthesis in the central nervous system of rats

Abstract

Nitrogen-containing bisphosphonates were found to inhibit farnesyl diphosphate synthase - an essential enzyme in the cholesterol biosynthesis pathway, but their effect on cholesterol synthesis per se in the central nervous system (CNS) remained unknown. This study brings the first experimental evidence of the inhibition of cholesterol biosynthesis with alendronate in CNS of rats.

Keywords

• brain cholesterol synthesis
• bisphosphonates
• alendronate
• deuterium oxide