Publication at Faculty of Medicine in Hradec Králové |
2009
Abstract
The aim of the study was to evaluate the expression of phosphorylated p38 mitogen-activated protein kinase (p38 MAPK) and MAPK-activated transcription factors elk-1, c-jun and c-myc in rat cerebellar Purkinje cells after soman poisoning to investigate the pathogenetic mechanism of non-specific long-term adverse effects of nerve agents. The results suggest that late activation of p38 MAPK and their targets might be the underlying mechanism of chronic neurophysiological adverse effects of soman.