Abstract
Retrospective analysis of pattern-reversal VEPs (R-VEPs) and motion-onset VEPs (M-VEPs) was performed in 20 patients with first attack of acute Optic Neuritis (ON) subsequently monitored for 36 - 135 months during which Multiple Sclerosis (MS) developed and was confirmed in 10 of them. The groups with MS and without MS did not differ significantly in the extent of pathological VEP findings: in MS patients, R-VEPs were abnormal in 100% and M-VEPs in 80% and the non-MS patients exhibited pathology in 80% of R-VEPs and in 90% of M-VEPs.
Although the inclusion of M-VEPs did not increase VEP examination sensitivity in ON patients, their use improves diagnostic reliability and enables monitoring of the parvocellular/magnocellular system and ventral/dorsal stream involvement of the visual pathway.