Abstract
Aging is the consequence of time on living organism. The adaptive mechanisms in senescence are decresed.
During senescence immunological varience increases as homeostatic reserve diminished. Aging is associated with a greater frequency of infection and neoplastic diseases.
Despite the involution of central organs of lymphocyte development, this changing does not lead to the same tape of immune deficiency as congenital defficiency of cell and humoral immunity. Immune senescence is more precisely characterised by shift in the number, distribution and activity of lymphocyte subsets, antibody specifiticies and cytokines.
This process leading to a state of immune dysregulation.: senescence; cytokines ; dysregulation