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Comorbidity of Parkinsonism and Schizophrenia in a Patient Treated with Clozapine

Publication at First Faculty of Medicine |
2003

Abstract

Clozapine is the least likely anti-psychotic to induce extrapyramidal symptoms (EPS). We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS.

Single photon emission computed tomography (SPECT) revealed a low density of presynaptic dopamine transporters in our patient's brain. A comorbid diagnosis of Parkinson's disease in schizophrenia was confirmed in this way.

This helped us to find a proper therapeutic strategy for our patient.