In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity

Abstract

In this study we examined the release kinetics of cTnT and cTnI using an in vitro model of NVCM and compared it with data from a model of anthracycline-induced cardiomyopathy in vivo. With 3 uM daunorubicin, the relative increase of AUC of cTnT and cTnI was 2.4 and 5.3-fold higher than the increase of LDH activity, respectively.

Keywords

• drug-induced cardiotoxicity
• anthracycline cardiotoxicity
• daunorubicin
• cardiac troponin I (cTnI)
• cardiac troponin T (cTnT)