The changes in the endothelial expression of cell adhesion molecules and iNOS in the vessel wall after the short-term administration of simvastatin in rabbit model of atherosclerosis

Abstract

The aim of this study was to detect and quantify changes in endothelial expression of P-selectin, VCAM-1, ICAM-1 and iNOS in the vessel wall after the short-term administration of simvastatin in a rabbit model of atherosclerosis. We conclude that simvastatin has beneficial effects on endothelial function by decreasing expression of P-selectin, ICAM-1 and iNOS in endothelial cells in the very early stages of atherogenesis.

Keywords

• changes
• endothelial
• expression
• adhesion
• molecules
• vessel
• after
• short-term
• administration
• simvastatin
• rabbit
• model
• atherosclerosis