Proliferative Markers in Diagnosis of Thyroid Tumors: A Comparative Study of MIB-1 and Topoisomerase II-a Immunostaining
2005
Abstract
The aim of our study was to evaluate the proliferative MIB-1 and topoisomerase II-alfa markers in both oncocytic and non-oncocytic epithelial thyroid tumors. Conclusion: PI can help the differential diagnosis of morphologically difficult cases of thyroid tumors.
Oncocytic adenomas have higher malignant potential and should be promptly surgically removed. Both MIB-1 and topoisomerase II-alfa are recommended for the evaluation of thyroid tumor cell proliferation.