Abstract
In two groups of 46 obese patients (the first group of 24 patients with short-term modified fasting, the second of 22 patients with a very low calorie diet) the authors confirmed the effect of modified fasting and a low calorie diet on the body weight and body mass index. They also proved in both groups a major decrease of cholesterol values and triacylglycerols and observed an increase of MPV during weight reduction.These results indicate that patientswith preexisting atherosclerosis and an increased MPV during weight reduction procedures are at high risk of contingent thromboembolic ischaemic events.MPV represents a simple routine haematological parameter, but a possible benefit from preventive treatment in patients with cardiovascular disease is unknown.