Emergence of fluoroquinolone resistance in Escherichia coli isolates at the Department of Clinical Hematology
Abstract
The aim of this study was to evaluate the dependence of Escherichia coli resistance to fluoroquinolones on their use in the outpatients and inpatients in the Hradec Kralove region of the Czech Republic. Data on inpatient fluoroquinolones use were obtained from the database of the Charles University Teaching Hospital Pharmacy, data on outpatient prescriptions were obtained from the database of the General Health Insurance Company and expressed in defined daily doses per 1000 clients per day (DID).
Escherichia coli strains were isolated from samples of urine of both community and hospitalized patients suffering from acute bacterial urinary tract infection, examined using aerobic cultivation, and determined by standard biochemical procedures. Results of this study shows the impact of fluoroquinolone utilization on Escherichia coli resistance, and support the need of controlled use of these effective antibiotics.