Abstract
Chronic B-lymphatic leukemia (B-CLL) is a low aggressive (malign) lymphoproliferative disease developing due to proliferation of clonal, malignantly transformed mature B-lymphocytes (1,2,9,16).This type of leukemia is the most frequent leukemia in adults in Europe and North America (30-40 % of all leukemias)(13). Its incidence in Europe is 3/100 000, twice more frequent in males than in females, and usually at over 50 years of age (1, 2, 9, 13).
Lymphotropic viri inhibiting the apoptosis in the attacked B-cell presumably assert in the etiology. The role of Epstein-Barr?s virus and bovine herpes virus (BHV-4) that induce the production of antiapoptic protein Bcl-2 in B-cells is discussed.
Even the adenoviri (E´1B55kDA) and papilloviri inhibiting the antiapoptic protein Bcl-2 are considered. The influence of radiation or chemical substances has not been proven in the etiopathology of B-CLL (13).