Cerebral toxoplasmosis in a patient with chronic myeloid leukemia after allogenic unrelated transplantation of haematopoietic cells
Abstract
The notion of myeloproliferative disease includes diseases caused by malign transformation of hemopoietic stem cells. The result of the transformation is an uncontrolled proliferation of hemopoietic stem cell with its following differentiation.
The disturbance of the pluripotent stem cell manifests in abnormal proliferation of the erythrocyte, granulocyte and megakaryocyte row, and in the course of time also by fibrotizatiom of bone marrow and extramedular hematopoiesis (in the spleen and in the liver). Usually, it is not an isolated proliferation of one row, but mostly also other rows are afflicted to a varying degree.
Single diseases of this group are genetically very unstable and the start of other changes leads to their transfer into acute leukemia. According to French-American-British classification (FAB) the myeloproliferative diseases are divided into: chronic myeloid leukemia, polycythaemia vera, essential thrombocytopenia and idiopathic myelofibrosis.