Publication at First Faculty of Medicine |
2003
Abstract
Highly reactive low-molecular compounds diisocyanates represent a significant cause of occupational asthma. Besides formaldehyde and latex, diisocyanates become a significant cause of occupational bronchial asthma (AB) in industrial countries, estimated prevalence of AB caused by diisocyanates is 5?15% of all exposed workers.
Diisocyanates (DI) are highly reactive aromatic and aliphatic compounds reacting with compounds rich in hydroxyl groups by polyaddition reaction resulting in polyurethanes. The most commonly used forms of DI are toluendiisocyanate (TDI), methylendiphenyldiisocyanate (MDI), hexamethylendiisocyanate (HDI).
They are irreplaceable in furniture-making, motor-car, electronic, clothing and refrigeration industry.