Is Defect in Phosphorylation of Nbs1 Responsible for High Radiosensitivity of T-Lymphocyte Leukemia Cells MOLT-4?

Abstract

Nbs1 is essential for activation of cell cycle check points and DNA repair in response to ionizing radiation. In this work we studied the molecular mechanisms regulating DNA repair and cell death in human T-lymphocyte leukemic cells, MOLT-4.

Keywords

• MOLT-4
• leukemia
• radiation
• Nbs1X
• DNA repair
• H2A.X
• phosphorylation