New findings in disorder of calcium and phosphate metabolism disorder in renal failure: clinical significance and relation to pharmacotherapy

Abstract

New findings about the phosphate and calcium metabolism disorder in renal failure are presented, especially focused on fetuin A (serum concentrations of this natural inhibitor of calcification are low in renal failure) and on the relation between vitamin D and extraosseous calcifications (possible protective role).

Keywords

• Phosphate calcium metabolism
• secondary hyperparathyroidism
• vascular calcification
• FGF-23 (fibroblast growth factor 23)
• fetuin A
• calcimimetics