Cytogenetic and immunological changes after dermal exposure to polycyclic aromatic hydrocarbons and UV radiation

Abstract

Goeckerman's therapy (GT), which combines exposure to coal tar (polycyclic aromatic hydrocarbons PAHs) and UV radiation (UV) is often used as the first option for treatment of psoriasis. The results indicate that GT could increase genotoxic risk and modulates immunity of treated patients.

Keywords

• Psoriasis
• UV-radiation
• Polycyclic aromatic hydrocarbons
• Genotoxic
• Immunotoxic.