Publication at First Faculty of Medicine |
2005
Abstract
We compared substrate utilisation in liver fibrosis or cirrhosis using microdialysis to follow interstitial concentration changes of urea, glucose, lactate and glycerol in peritoneal cavity, liver and thymus. Lower availability of glucose and lactate production in thymus in rats with chronic liver failure, thymocytes are not able to proliferate.
Fluctuation or decrease of interstitial concentrations of these metabolities could be explanation of pathophysiological changes in distant organs. The impairment of glucose metabolism may be the cause of pathophysiological changes in thymus.