The importance of abrogation of G(2)-phase arrest in combined effect of TRAIL and ionizing radiation

Abstract

In this work we studied the relationship between the enhanced expression of DR5 receptor and the effect of combination of TRAIL and ionizing radiation on cell cycle arrest and apoptosis induction in human leukemia cell line HL-60.

Keywords

• TRAIL
• apoptosis
• ionizing radiation
• call cycle arrest
• DR5