Temporal patterns of electrical remodeling in canine ventricular hypertrophy: Focus on IKs downregulation and blunted ß-adrenergic activation

Abstract

In the study the tempoval patterns of downregulation of IKs channel subunits and of beta-adrenergic receptors in dogs with chronic AV-block were investigated. The mRNA and protein levels were correlated with functional data and the arrhythmogenic consequences were shown.

Keywords

• Temporal
• patterns
• electrical
• remodeling
• canine
• ventricular
• hypertrophy
• Focus
• downregulation
• blunted
• ß-adrenergic
• activation