Voltammetric detection of damage to DNA caused by nitro derivatives of fluorene using an electrochemical DNA biosensor

Abstract

An electrochemical DNA biosensor based on the screen printed carbon paste electrode (SPCPE) with an immobilized layer of calf thymus double-stranded DNA has been used for in vitro investigation of the interaction between genotoxic nitro derivatives of fluorene (namely 2-nitrofluorene and 2,7-dinitrofluorene) and DNA.

Keywords

• 2-nitrofluorene
• 2,7-dinitrofluorene
• DNA biosensor
• screen printed carbon paste electrode
• electrochemical detection
• DNA damage