Chemical, radiochemical and biological studies of Sm and Ho complexes of H4dota analogues containing one methylphosphonic / phosphinic acid pendant arm

Abstract

This work intends to investigate samarium and holmium complexes with a set of H(4)dota-analogues bearing methylphosphonate/methylphosphinic acid pendant arms (H(5)do3ap, H(5)do3ap(PrA) and H(4)do3aP(ABn)) as new bifunctional ligands for radiolanthanide targeted therapy. Radiolanthanide complexes of these ligands were prepared and evaluated as potential therapeutical agents.

Thermodynamic solution studies were also performed to get a better insight on the radiochemical results.

Keywords

• bone pain palliation
• MRI contrast agents
• skeletal targeted radiotherapy
• absorbed dose estimation
• water exchange-rate
• lanthanide(III) complexes
• Ho-166 complexes
• multiple-myeloma
• potential agents
• DOTA analog