Prognosis of children with mixed phenotype acute leukemia treated on the basis of consistent immunophenotypic criteria

Abstract

Mixed phenotype acute leukemia (MPAL) represents a diagnostic and therapeutic dilemma. The incidences of MPAL were 28/582 and 4/107 for children treated with acute lymphoblastic leukemia and acute myeloid leukemia regimens, respectively.

The small numbers of MPAL cases treated as T-cell acute lymphoblastic leukemia or as acute myeloid leukemia hampered separate statistics. We compared prognosis of all subsets with the prognosis of previously published cohorts.

Keywords

• pediatric acute lymphoblastic leukomia
• pediatric acute myeloid leukemia
• mixed phenotype leukemia
• biphenotypic leukemia
• aberrant antigens
• cytometry
• acute hybrid leukemia