Cyclodextrin-Based Bimodal Fluorescence/MRI Contrast Agents: An Efficient Approach to Cellular Imaging
2010
Abstract
A novel bimodal fluorescence/MRI probe based on a cyclodextrin scaffold has been synthesized and characterized. The agent is not cytotoxic and is easily internalized into cells.
The labelled cells can be visualized by MRI, as proved by the detection of individual labelled pancreatic islets. A fluorescence study performed on mesenchymal stem cells showed that the agent stays in the intracellular space for a long time.