381 Cas is a relatively bright and early-type eclipsing binary system. Several new times of its eclipses were measured as part of our long-term observational project of eccentric eclipsing binaries.
Based on a current O-C diagram solution, we found for the first time that its orbit is slightly eccentric (e = 0.025) and shows a very rapid apsidal advance with short period of about 20 years only. The relativistic and third body effects are negligible, being about 3% of the total apsidal motion rate.