Publication at Faculty of Medicine in Hradec Králové |
2010
Abstract
The permanent hypopituitarism was found in one quarter to one half of patients after traumatic brain injury. The most common turned out to be the growth hormone (12.9%) and gonadotropic (11.1%) insufficiency.
Less common is the corticotrophic (7.5%) and hydrotropic (4.9%) insufficiency. In the majority of patients an isolated dysfunction was discovered.
In 9%, however, a combined failure of two of more pituitary axis was present. This paper describes the minimum investigation needed to diagnose hypopituitary patients after TBI, who may profit from substitution therapy.