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MTDLs
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publication
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
2015 |
Publication without faculty affiliation
publication
Riluzole-Rasagiline Hybrids: Toward the Development of Multi-Target-Directed Ligands for Amyotrophic Lateral Sclerosis
2022 |
Publication without faculty affiliation
publication
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity
2015 |
Publication without faculty affiliation
publication
Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimer's drugs dealing with cholinergic, amyloid and mitochondrial systems
2021 |
Central Library of Charles University, Faculty of Medicine in Hradec Králové
publication
(+/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3 beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease
2021 |
Publication without faculty affiliation
publication
Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy
2021 |
Publication without faculty affiliation
publication
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease
2017 |
Publication without faculty affiliation
publication
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease
2021 |
Publication without faculty affiliation
publication
Donepezil derivatives targeting amyloid-beta cascade in Alzheimer's disease
2019 |
Publication without faculty affiliation
publication
Novel propargylamine-based inhibitors of cholinesterases and monoamine oxidases: Synthesis, biological evaluation and docking study
2021 |
Faculty of Pharmacy in Hradec Králové
publication
Effects of Novel Tacrine Derivatives on Mitochondrial Energy Metabolism and Monoamine Oxidase Activity-In Vitro Study
2021 |
First Faculty of Medicine
publication
Profiling donepezil template into multipotent hybrids with antioxidant properties
2018 |
Publication without faculty affiliation
publication
Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease
2019 |
Publication without faculty affiliation
publication
Multitarget tacrine hybrids with neuroprotective properties to confront Alzheimer's disease
2017 |
Publication without faculty affiliation