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PXR
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publication
Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation
2009 |
First Faculty of Medicine
publication
Resveratrol as an Inhibitor of Pregnane X Receptor (PXR): Another Lesson in PXR Antagonism
2014 |
Faculty of Pharmacy in Hradec Králové
publication
Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions
2016 |
Faculty of Pharmacy in Hradec Králové
publication
Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression
2008 |
Central Library of Charles University
publication
Marine Ligands of the Pregnane X Receptor (PXR): An Overview
2019 |
Faculty of Pharmacy in Hradec Králové
publication
Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene
2011 |
Faculty of Pharmacy in Hradec Králové
publication
Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor
2017 |
Faculty of Pharmacy in Hradec Králové
publication
Allosteric Antagonism of the Pregnane X Receptor (PXR): Current-State-of-the-Art and Prediction of Novel Allosteric Sites
2022 |
Faculty of Pharmacy in Hradec Králové
publication
Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways
2007 |
Publication without faculty affiliation
publication
Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 Superfamily
2013 |
Faculty of Pharmacy in Hradec Králové
publication
Drug interaction with membrane transporters and nuclear receptors
Publication without faculty affiliation
publication
The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids
2020 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction
2018 |
Faculty of Pharmacy in Hradec Králové, Faculty of Science
publication
Unexpected Effects of Propiconazole, Tebuconazole, and Their Mixture on the Receptors CAR and PXR in Human Liver Cells
2018 |
Faculty of Pharmacy in Hradec Králové
publication
Valproic acid induces CYP3A4 expression through Pregnane X (PXR) and Constitutive androstane (CAR) nuclear receptor pathways
Publication without faculty affiliation
publication
Role of extracellular-signal regulated kinase (ERK) pathway in PXR-mediated valproic acid-induced activation of CYP3A4 expression
Publication without faculty affiliation
publication
Rifampicin does not significantly affect the expression of small heterodimer partner in primary human hepatocytes
2012 |
Faculty of Pharmacy in Hradec Králové
publication
Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation
2017 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
Stereoselective interactions of warfarin enantiomers with the pregnane X nuclear receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes
2010 |
Faculty of Pharmacy in Hradec Králové
publication
U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells
2014 |
Faculty of Pharmacy in Hradec Králové
publication
Investigation of Orlistat effects on PXR activation and CYP3A4 expression in primary human hepatocytes and human intestinal LS174T cells
2010 |
Central Library of Charles University
publication
The pregnane X receptor: from bench to bedside
2008 |
First Faculty of Medicine
publication
2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists
2016 |
Faculty of Pharmacy in Hradec Králové
publication
A Double Transgenic Mouse Model Expressing Human Pregnane X Receptor and Cytochrome P450 3A4
2008 |
First Faculty of Medicine
publication
Dietary phytochemicals as modulators of human pregnane X receptor
2023 |
Faculty of Pharmacy in Hradec Králové
publication
Pharmacological importance of orphan nuclear receptors
2014 |
First Faculty of Medicine
publication
Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism
2021 |
Faculty of Pharmacy in Hradec Králové
publication
Pregnane X Receptor and Cancer: Context-Specificity is Key
2016 |
Faculty of Pharmacy in Hradec Králové
publication
The role of residues T248, Y249 and T422 in the function of human pregnane X receptor
2013 |
Faculty of Pharmacy in Hradec Králové
publication
The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator
2016 |
Faculty of Pharmacy in Hradec Králové